Enola Holmes: Finder of Lost Souls is an opposed cooperative game of reasoning and deception for two to four players. One player is the Criminal, hatching a sinister plan to abduct their victim, leaving puzzling clues in their wake. The other players are the Detectives, working together to solve these Puzzles and reveal Clues. If they solve enough Puzzles and use careful Deduction, they can deduce the Crime and stop the Criminal.

The Detectives have 4 turns to gather Clues and make Deductions. If they Deduce the Crime in that time, the Detectives win. If they fail to Deduce the Crime, the Criminal wins.