1-4 players take turns playing loot cards and using items to kill monsters that yield more items, loot, and sometimes souls. The first player to end their turn with 4 souls is the winner. Cooperation, barter, and betrayal is encouraged. 

This is the Second Edition of The Binding of Isaac: Four Souls. All cards have been updated with enhanced backgrounds and updated wording for clarity.

The Box Contains:

• 340 The Binding of Isaac: Four Souls 2nd Edition cards
• 100 plastic pennies
• 1 D6 & 1 D8
• The rulebook