In House of 1000 Corpses, an co-operative board game based on the movie of the same name, players take on the roles of the Firefly family. They must scour their house, looking for the people hiding there, and bring them to Dr. Satan before too many rounds pass. They do this using an action system that penalizes the players for doing too many of the same action in a row.

During the game players use their Action cards to Move, Search, Kill, or Capture their victims hiding in the house. The game includes 3 different difficulty modes with varying victory conditions, as well as solitaire rules.