Braaiiinns! It’s the sickest, silliest Munchkin yet! The players are zombies, kicking down doors and eating brains. The “monsters” they’re attacking are people, some helpless and some hazardous, with a few rogue zombies thrown in. The armor is whatever they’ve blundered across during their lurching search for brains. So bravely the munchkins go forth, with mousetraps on their feet and a bowling trophy protecting their poor rotting heads . . . to level up, or to die. Again.

In a reversal of roles, all players in Munchkin Zombies start out as zombies, and the "monsters" are the normal people trying to stop the zombie invasion (such as the Action Hero, Soccer Mom, Fireman, etc.). Unlike most Munchkin games, there are no classes or races; instead, you can have a mojo: Atomic Zombie, Plague Zombie, and Voodoo Zombie.

As with Munchkin Bites! and Super Munchkin, Munchkin Zombies includes powers – special abilities that you can play as you gain levels.